Triphenyl-1,3-Dioxolan-2-Ylmethyl-Phosphonium Bromide

Triphenyl-1,3-Dioxolan-2-Ylmethyl-Phosphonium Bromide - Names and Identifiers

Name	(1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide
Synonyms	LABOTEST-BB LT00233112 (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide Triphenyl-1,3-Dioxolan-2-Ylmethyl-Phosphonium Bromide Phosphonium, (1,3-Dioxolan-2-Ylmethyl)Triphenyl-, Bromide 2-(1,3)-Dioxolane-2-Yl-Methyltriphenylphosphonium Bromide (1,3-Dioxolane-2-Yl Methyl) Triphenyl Phosphonium Bromide 2-[(1,3)-dioxolane-2-yl]-methyltriphenylphosphonium bromide
CAS	52509-14-5
EINECS	257-977-3
InChI	InChI=1/C22H22O2P.BrH/c1-4-10-19(11-5-1)25(18-22-23-16-17-24-22,20-12-6-2-7-13-20)21-14-8-3-9-15-21;/h1-15,22H,16-18H2;1H/q+1;/p-1
InChIKey	FRHRVQQUICVJDG-UHFFFAOYSA-M

Triphenyl-1,3-Dioxolan-2-Ylmethyl-Phosphonium Bromide - Physico-chemical Properties

Molecular Formula	C22H24BrO2P
Molar Mass	431.3
Melting Point	193-195℃
Water Solubility	Soluble in water (20°C).
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Powder or Crystals
Color	White to light brown
Storage Condition	Store below +30°C.
Sensitive	Hygroscopic
MDL	MFCD00011966
Use	Used for the preparation of proportional fluorescent probes, especially for the determination of cysteine by homocysteine and glutathione; used for microwave-assisted synthesis of KN-93 as calmodulin type II activase; used for the preparation of fluorinated spirovanidone piperidine as s1 receptor ligand; used for synthesis and anti-tumor additives; used for regioselective preparation of indole derivatives by rhodium-catalyzed domino hydroformylation/indole reaction

Triphenyl-1,3-Dioxolan-2-Ylmethyl-Phosphonium Bromide - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29329970

Triphenyl-1,3-Dioxolan-2-Ylmethyl-Phosphonium Bromide - Introduction

(1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide is an organic compound with the chemical formula [C6H5]3PBr. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystalline solid
-Melting point: 182-186°C
-Solubility: Soluble in organic solvents such as ether and alcohol, insoluble in water
-Molecular weight: 547.21g/mol

Use:
(1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide are mainly used for catalytic reactions in organic synthesis. It is usually used as a bromine source catalyst and can participate in a variety of reactions, such as the synthesis of organic phosphorus reagents, and the esterification of catalytic bases.

Preparation Method:
The preparation of (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide can be carried out by the following steps:
1. Under appropriate conditions, triphenylphosphine is reacted with sulfoxide bromide (or hydrogen bromide) to obtain triphenylphosphine bromide.
2. epoxidizing triphenylphosphine bromide with 1,3-propanediol to generate (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide.

Safety Information:
- (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide is potentially dangerous and requires appropriate safety measures for use and storage.
-Wear appropriate personal protective equipment such as gloves, goggles and lab coats during use.
-Avoid contact with skin and eyes. If you come into contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
-Store in a sealed container, away from fire and oxidizing agents.

Please note that the use and handling of chemicals should comply with relevant safety regulations and operating guidelines. When using this compound in a laboratory or industrial setting, be sure to follow the guidance of a professional.

Last Update：2024-04-10 22:29:15